From realflow I know the procedure to run a simulation without updating frames. e.g. I want to fill a glass with water and simulate until the water settles. Then I want to use this as an initial state for my further animation/simulation.

Is there a way to run only the simulation in houdini without turning off all other animation manually?

Hi

you can save data from simulated frame that you want using ROP Output in DOPS and then use it as initial state. You can find Initial state on Simulation TAB of the DOP node on the object level.