I've been working on a hair simulation, and found that when self collisions were enabled, my wires had a lot of erratic self collisions. Disabling self-collisions resolved the situation, but wasn't preferable. I figured out that reducing the resolution of my wires actually made the sim a lot more stable, effectively removing the self-collision problem, while still looking good. There's a limited amount of Wire/Hair info on the forum, so I hope this will help someone in need who experienced this same issue.

Cheers